Synthesis of Novel 6,7,8,9-Tetrahydro-5H-5-hydroxyphenyl-2-benzylidine-3-substituted Hydrazino Thiazolo (2,3-b) Quinazoline as Potent Antinociceptive and Anti-inflammatory Agents
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چکیده
منابع مشابه
Synthesis and anti-microbial screening of some new 6,7,8,9-Tetrahydro-5H-5-(2'-hydroxyphenyl)-2-(4'- substitutedbenzylidine)-3-(4-nitrophenylamino) thiazoloquinazoline derivatives
Synthesis and anti-microbial screening thiazoloquinazoline derivatives Abstract A series of some new 6,7,8,9-Tetrahydro-5H-5(2'-hydroxyphenyl)-2-(4'-fluorobenzylidine)-3-(4nitrophenyl amino) thiazolo quinazoline (4a-4d) and 6,7,8,9-Tetrahydro-5H-5-(2'-hydroxy phenyl)2-(4'-substituted benzylidine)-3-(4-nitrophenyl amino) thiazolo quinazoline (5a-5d) derivatives were synthesized. The in vitro ant...
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The series of 6,7,8,9-tetrahydro-5H-5-(2'-hydroxyphenyl)-2-(4'-substituted benzylidine)thiazolo(2,3-b)quinazolin-3(2H)-ones (4a-j) and 6,7,8,9-tetrahydro-5H-5-(2'-hydroxyphenyl)-2-(4'-substituted benzylidine)-3-(4-nitrophenyl amino)thiazoloquinazolines (5a-j) were synthesized by the reported method and evaluated for their phosphodiesterase inhibitory activity. All test compounds exhibited good ...
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A series of novel 3-cyclohexyl-2-substituted hydrazino-quinazolin-4(3H)-ones were synthesized by reacting the amino group of 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one with a variety of aldehydes and ketones. The starting material, 3-cyclohexyl-2-hydrazino quinazolin-4(3H)-one, was synthesized from cyclohexyl amine. Title compounds were investigated for analgesic, anti-inflammatory and ulcer...
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An optimized method for the synthesis of new 2-substituted-thiazolo[2,3-a]benzimidazole-3(2H)-ones was developed which enabled the target compounds to be obtained in relative good yields through one pot process.Four cancer cell lines: human colorectal cancer cell line HT-29, breast cancer cells MDA-MB-231, cervical cancer cells HeLa, human liver carcinoma cell line HepG2 and human diploid cell ...
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Diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the lethal gastro intestinal (GI) toxicities, diclofenac sodium is not an exception. The free –COOH group is thought to be responsible for the GI toxicity associated with all traditional NSAIDs. In the present research, the main motto...
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ژورنال
عنوان ژورنال: Bulletin of the Korean Chemical Society
سال: 2010
ISSN: 0253-2964
DOI: 10.5012/bkcs.2010.31.11.3265